BriX: a database of protein building blocks for structural analysis, modeling and design.

ABSTRACT: High-resolution structures of proteins remain the most valuable source for understanding their function in the cell and provide leads for drug design. Since the availability of sufficient protein structures to tackle complex problems such as modeling backbone moves or docking remains a problem, alternative approaches using small, recurrent protein fragments have been employed. Here we present two databases that provide a vast resource for implementing such fragment-based strategies. The BriX database contains fragments from over 7000 non-homologous proteins from the Astral collection, segmented in lengths from 4 to 14 residues and clustered according to structural similarity, summing up to a content of 2 million fragments per length. To overcome the lack of loops classified in BriX, we con

SUBMITTER: Vanhee P 

PROVIDER: S-EPMC3013806 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature