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Capabilities of liposomes for topological transformation.

ABSTRACT: Dynamic behaviors of liposomes caused by interactions between liposomal membranes and surfactant were studied by direct real-time observation by using high-intensity dark-field microscopy. Solubilization of liposomes by surfactants is thought to be a catastrophic event akin to the explosion of soap bubbles in the air; however, the actual process has not been clarified. We studied this process experimentally and found that liposomes exposed to various surfactants exhibited unusual behavior, namely continuous shrinkage accompanied by intermittent quakes, release of encapsulated liposomes, opening up, and inside-out topological inversion.

SUBMITTER: Nomura F

PROVIDER: S-EPMC30140 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature

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Capabilities of liposomes for topological transformation.

Nomura F F Nagata M M Inaba T T Hiramatsu H H Hotani H H Takiguchi K K

Proceedings of the National Academy of Sciences of the United States of America 20010220 5

Dynamic behaviors of liposomes caused by interactions between liposomal membranes and surfactant were studied by direct real-time observation by using high-intensity dark-field microscopy. Solubilization of liposomes by surfactants is thought to be a catastrophic event akin to the explosion of soap bubbles in the air; however, the actual process has not been clarified. We studied this process experimentally and found that liposomes exposed to various surfactants exhibited unusual behavior, namel ...[more]

PMID: 11226241

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