IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group.

ABSTRACT:

Purpose

Recent studies have demonstrated a high frequency of IDH mutations in adult "secondary" malignant gliomas arising from preexisting lower grade lesions, often in young adults, but not in "primary" gliomas. Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations.

Experimental design

We examined the frequency of IDH mutations, using real-time polymerase chain reaction and sequencing analysis, in a cohort of 43 pediatric primary malignant gliomas treated on the Children's Oncology Group ACNS0423 study. The relationship between IDH mutations and other molecular and clinical factors, and outcome, was evaluated.

Results

IDH1 mutations were observed in 7

SUBMITTER: Pollack IF 

PROVIDER: S-EPMC3014378 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature