Ontology highlight
ABSTRACT:
SUBMITTER: Konev AY
PROVIDER: S-EPMC3014568 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20070801 5841
The organization of chromatin affects all aspects of nuclear DNA metabolism in eukaryotes. H3.3 is an evolutionarily conserved histone variant and a key substrate for replication-independent chromatin assembly. Elimination of chromatin remodeling factor CHD1 in Drosophila embryos abolishes incorporation of H3.3 into the male pronucleus, renders the paternal genome unable to participate in zygotic mitoses, and leads to the development of haploid embryos. Furthermore, CHD1, but not ISWI, interacts ...[more]