Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity.

ABSTRACT:

Background

Obesity is reaching epidemic proportions and represents a significant risk factor for cardiovascular disease, diabetes, and cancer.

Methods

To explore the relationship between increased body mass and gene expression in blood, we conducted whole-genome expression profiling of whole blood from seventeen obese and seventeen well matched lean subjects. Gene expression data was analyzed at the individual gene and pathway level and a preliminary assessment of the predictive value of blood gene expression profiles in obesity was carried out.

Results

Principal components analysis of whole-blood gene expression data from obese and lean subjects led to efficient separation of the two cohorts. Pathway analysis by gene-set enrichment demonstrated increased transcript l

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC3014865 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature