Post-transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation.

ABSTRACT: Over 50 years of biological research with bacteriophage T4 includes notable discoveries in post-transcriptional control, including the genetic code, mRNA, and tRNA; the very foundations of molecular biology. In this review we compile the past 10-15 year literature on RNA-protein interactions with T4 and some of its related phages, with particular focus on advances in mRNA decay and processing, and on translational repression. Binding of T4 proteins RegB, RegA, gp32 and gp43 to their cognate target RNAs has been characterized. For several of these, further study is needed for an atomic-level perspective, where resolved structures of RNA-protein complexes are awaiting investigation. Other features of post-transcriptional control are also summarized. These include: RNA structure at translatio

SUBMITTER: Uzan M 

PROVIDER: S-EPMC3014915 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature