A solute-binding protein for iron transport in Streptococcus iniae.

ABSTRACT:

Background

Streptococcus iniae (S. iniae) is a major pathogen that causes considerable morbidity and mortality in cultured fish worldwide. The pathogen's ability to adapt to the host affects the extent of infection, hence understanding the mechanisms by which S. iniae overcomes physiological stresses during infection will help to identify potential virulence determinants of streptococcal infection. Grow S. iniae under iron-restricted conditions is one approach for identifying host-specific protein expression. Iron plays an important role in many biological processes but it has low solubility under physiological condition. Many microorganisms have been shown to be able to circumvent this nutritional limitation by forming direct contacts with iron-containing proteins through ATP-bind

SUBMITTER: Zou L 

PROVIDER: S-EPMC3014919 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature