Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster.

ABSTRACT:

Background

The pathophysiological basis of severe respiratory syncytial virus (RSV) bronchiolitis in infancy is poorly understood and has hindered vaccine development. Studies implicate the cell-mediated immune response in the pathogenesis of the disease. A recent twin study estimated a heritable contribution of 22% to RSV bronchiolitis. Genetic epidemiology provides a new approach to identifying important immune determinants of disease severity.

Methods

A comprehensive high-density gene-region association study for severe RSV bronchiolitis in infancy at 5q31 across 11 genes including the Th2-cytokine cluster was performed. A haplotype tagging approach was used to analyse genetic variation at 113 single nucleotide polymorphisms (SNPs) in 780 independent cases and 1045 contro

SUBMITTER: Forton JT 

PROVIDER: S-EPMC3015100 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature