Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial.

ABSTRACT:

Context

Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI).

Objective

To determine whether out-of-hospital administration of hypertonic fluids improves neurologic outcome following severe TBI.

Design, setting, and participants

Multicenter, double-blind, randomized, placebo-controlled clinical trial involving 114 North American emergency medical services agencies within the Resuscitation Outcomes Consortium, conducted between May 2006 and May 2009 among patients 15 years or older with blunt trauma and a prehospital Glasgow Coma Scale score of 8 or less who did not meet criteria for h

SUBMITTER: Bulger EM 

PROVIDER: S-EPMC3015143 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature