The potential interaction between clopidogrel and proton pump inhibitors: a systematic review.

ABSTRACT:

Background

Recently, several publications have investigated a possible drug interaction between clopidogrel and proton pump inhibitors (PPIs), and regulatory agencies have issued warnings despite discordant study results. In an attempt to clarify the situation, we performed a systematic review with a critical analysis of study methodologies to determine whether varying study quality (that is, bias) could explain the discordant results.

Methods

A systematic review of all studies reporting clinical outcomes was performed using an electronic literature search of the MEDLINE and EMBASE databases, abstracts from the major cardiology conferences and a hand-search of bibliographies from identified articles. Each study was evaluated for its risk of bias according to a prespecified q

SUBMITTER: Lima JP 

PROVIDER: S-EPMC3016262 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature