Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish.

ABSTRACT:

Background

Development of the posterior lateral line (PLL) system in zebrafish involves cell migration, proliferation and differentiation of mechanosensory cells. The PLL forms when cranial placodal cells delaminate and become a coherent, migratory primordium that traverses the length of the fish to form this sensory system. As it migrates, the primordium deposits groups of cells called neuromasts, the specialized organs that contain the mechanosensory hair cells. Therefore the primordium provides both a model for studying collective directional cell migration and the differentiation of sensory cells from multipotent progenitor cells.

Results

Through the combined use of transgenic fish, Fluorescence Activated Cell Sorting and microarray analysis we identified a repertoire of

SUBMITTER: Gallardo VE 

PROVIDER: S-EPMC3016277 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature