Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index.

ABSTRACT:

Background

A recent study reported that the fatness associated A-allele of FTO rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness. We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish men.

Methodology/principal findings

In a population of 362,200 young men, examined for military service between 1943 and 1977, two groups were identified: 1) a random 1% sample and 2) all obese men (BMI = 31.0 kg/m(2), all of whom were above the 99(th) percentile of this population). At an average age of 49 years (range: 39 through 65 years), 551 men, hereof 231 of the obese, were re-ex

SUBMITTER: Zimmermann E 

PROVIDER: S-EPMC3016333 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature