Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice.

ABSTRACT: The mouse is an important model organism for investigating the molecular mechanisms of body weight regulation, but a quantitative understanding of mouse energy metabolism remains lacking. Therefore, we created a mathematical model of mouse energy metabolism to predict dynamic changes of body weight, body fat, energy expenditure, and metabolic fuel selection. Based on the principle of energy balance, we constructed ordinary differential equations representing the dynamics of body fat mass (FM) and fat-free mass (FFM) as a function of dietary intake and energy expenditure (EE). The EE model included the cost of tissue deposition, physical activity, diet-induced thermogenesis, and the influence of FM and FFM on metabolic rate. The model was calibrated using previously published data and valid

SUBMITTER: Guo J 

PROVIDER: S-EPMC3016341 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature