Knobbed acrosome defect is associated with a region containing the genes STK17b and HECW2 on porcine chromosome 15.

ABSTRACT:

Background

Male infertility is an increasing problem in all domestic species including man. Localization and identification of genes involved in defects causing male infertility provide valuable information of specific events in sperm development. Correct condensation of the sperm head and development of the acrosome are required for fertile sperm. In the Finnish Yorkshire pig population a knobbed acrosome defect (KAD) has been reported which appears to be of genetic origin. In previous studies we have shown that a large number of affected spermatozoa have a cystic swelling anterior to the apical part of the acrosome.

Results

Characterization of the knobbed acrosome affected sperm revealed that both the acrosomal granules and chromatin are affected. This type of KAD appears

SUBMITTER: Sironen A 

PROVIDER: S-EPMC3016419 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature