Histone demethylation and timely DNA replication.

ABSTRACT: It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.

SUBMITTER: Gerace EL 

PROVIDER: S-EPMC3016942 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature