Ontology highlight
ABSTRACT:
SUBMITTER: Chen XW
PROVIDER: S-EPMC3016972 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chen Xiao-Wei XW Leto Dara D Xiong Tingting T Yu Genggeng G Cheng Alan A Decker Stuart S Saltiel Alan R AR
Molecular biology of the cell 20101209 1
Insulin stimulates glucose transport in muscle and adipose tissue by translocation of glucose transporter 4 (GLUT4) to the plasma membrane. We previously reported that activation of the small GTPase RalA downstream of PI 3-kinase plays a critical role in this process by mobilizing the exocyst complex for GLUT4 vesicle targeting in adipocytes. Here we report the identification and characterization of a Ral GAP complex (RGC) that mediates the activation of RalA downstream of the PI 3-kinase/Akt p ...[more]