Systematic review of the evidence relating FEV1 decline to giving up smoking.

ABSTRACT:

Background

The rate of forced expiratory volume in 1 second (FEV1) decline ("beta") is a marker of chronic obstructive pulmonary disease risk. The reduction in beta after quitting smoking is an upper limit for the reduction achievable from switching to novel nicotine delivery products. We review available evidence to estimate this reduction and quantify the relationship of smoking to beta.

Methods

Studies were identified, in healthy individuals or patients with respiratory disease, that provided data on beta over at least 2 years of follow-up, separately for those who gave up smoking and other smoking groups. Publications to June 2010 were considered. Independent beta estimates were derived for four main smoking groups: never smokers, ex-smokers (before baseline), quitters (

SUBMITTER: Lee PN 

PROVIDER: S-EPMC3017006 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature