Functional cooperation of of IL-1β and RGS4 in the brachial plexus avulsion mediated brain reorganization.

ABSTRACT:

Backgrounds

There is considerable evidence that central nervous system is continuously modulated by activity, behavior and skill acquisition. This study is to examine the reorganization in cortical and subcortical regions in response to brachial plexus avulsion.

Methods

Adult C57BL/6 mice were divided into four groups: control, 1, 3 and 6 month of brachial plexus avulsion. IL-1β, IL-6 and RGS4 expression in cortex, brainstem and spinal cord were detected by BiostarM-140 s microarray and real-time PCR. RGS4 subcellular distribution and modulation were further analyzed by primary neuron culture and Western Blot.

Results

After 1, 3 and 6 months of brachial plexus avulsion, 49 (0 up, 49 down), 29 (17 up, 12 down), 13 (9 up, 4 down) genes in cerebral cortex, 40 (8 up, 32 d

SUBMITTER: Li J 

PROVIDER: S-EPMC3017042 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature