External validation of the UK Prospective Diabetes Study (UKPDS) risk engine in patients with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Treatment guidelines recommend the UK Prospective Diabetes Study (UKPDS) risk engine for predicting cardiovascular risk in patients with type 2 diabetes, although validation studies showed moderate performance. The methods used in these validation studies were diverse, however, and sometimes insufficient. Hence, we assessed the discrimination and calibration of the UKPDS risk engine to predict 4, 5, 6 and 8 year cardiovascular risk in patients with type 2 diabetes.

Methods

The cohort included 1,622 patients with type 2 diabetes. During a mean follow-up of 8 years, patients were followed for incidence of CHD and cardiovascular disease (CVD). Discrimination and calibration were assessed for 4, 5, 6 and 8 year risk. Discrimination was examined using the c-statis

SUBMITTER: van Dieren S 

PROVIDER: S-EPMC3017299 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature