Hydrodynamic regulation of monocyte inflammatory response to an intracellular pathogen.

ABSTRACT: Systemic bacterial infections elicit inflammatory response that promotes acute or chronic complications such as sepsis, arthritis or atherosclerosis. Of interest, cells in circulation experience hydrodynamic shear forces, which have been shown to be a potent regulator of cellular function in the vasculature and play an important role in maintaining tissue homeostasis. In this study, we have examined the effect of shear forces due to blood flow in modulating the inflammatory response of cells to infection. Using an in vitro model, we analyzed the effects of physiological levels of shear stress on the inflammatory response of monocytes infected with chlamydia, an intracellular pathogen which causes bronchitis and is implicated in the development of atherosclerosis. We found that chlamydial i

SUBMITTER: Evani SJ 

PROVIDER: S-EPMC3017540 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature