Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.

ABSTRACT:

Scope

Phenethyl isothiocyanate (PEITC) is a constituent of cruciferous vegetables that has demonstrated cancer preventive activity in a number of cancer models including lung, prostate, and breast cancer. Our objective was to examine the effects of the oral administration of PEITC for 7 days on the hepatic expression of genes important in drug metabolism and toxicity in Sprague Dawley rats. The liver is the major site for the metabolism of various xenobiotics and carcinogens, and determining the effects of PEITC on the gene expression of hepatic enzymes may provide insight into mechanisms underlying the cancer preventive activity of PEITC.

Methods and results

Using a microarray containing 282 genes, we observed that PEITC significantly up-regulated UDP-glucuronosyltransferas

SUBMITTER: Telang U 

PROVIDER: S-EPMC3017723 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature