Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis.

ABSTRACT:

Introduction

In the last few years, various studies have underlined a correlation between thyroid function and male sexual function, hypothesizing a direct action of thyroid hormones on the penis.

Aim

To study the spatiotemporal distribution of mRNA for the thyroid hormone nuclear receptors (TR) alpha1, alpha2 and beta in the penis and smooth muscle cells (SMCs) of the corpora cavernosa of rats and humans during development.

Methods

We used several molecular biology techniques to study the TR expression in whole tissues or primary cultures from human and rodent penile tissues of different ages.

Main outcome measure

We measured our data by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) amplification, Northern blot and immunohistochemi

SUBMITTER: Carosa E 

PROVIDER: S-EPMC3017743 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature