Conserved and variable correlated mutations in the plant MADS protein network.

ABSTRACT:

Background

Plant MADS domain proteins are involved in a variety of developmental processes for which their ability to form various interactions is a key requisite. However, not much is known about the structure of these proteins or their complexes, whereas such knowledge would be valuable for a better understanding of their function. Here, we analyze those proteins and the complexes they form using a correlated mutation approach in combination with available structural, bioinformatics and experimental data.

Results

Correlated mutations are affected by several types of noise, which is difficult to disentangle from the real signal. In our analysis of the MADS domain proteins, we apply for the first time a correlated mutation analysis to a family of interacting proteins. This p

SUBMITTER: van Dijk AD 

PROVIDER: S-EPMC3017862 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature