Integrated genomics of susceptibility to alkylator-induced leukemia in mice.

ABSTRACT:

Background

Therapy-related acute myeloid leukemia (t-AML) is a secondary, generally incurable, malignancy attributable to chemotherapy exposure. Although there is a genetic component to t-AML susceptibility in mice, the relevant loci and the mechanism(s) by which they contribute to t-AML are largely unknown. An improved understanding of susceptibility factors and the biological processes in which they act may lead to the development of t-AML prevention strategies.

Results

In this work we applied an integrated genomics strategy in inbred strains of mice to find novel factors that might contribute to susceptibility. We found that the pre-exposure transcriptional state of hematopoietic stem/progenitor cells predicts susceptibility status. More than 900 genes were differentially

SUBMITTER: Cahan P 

PROVIDER: S-EPMC3018144 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature