Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: a randomized controlled trial.

ABSTRACT:

Objective

To assess short-term efficacy of single intraarticular botulinum toxin (IA-BoNT/A) injection in patients with chronically painful total knee arthroplasty (TKA) in a randomized, placebo-controlled, triple-blind study.

Methods

Patients with chronic TKA pain (pain > 6 on 0-10 scale and > 6 months post-TKA) evaluated in and referred from orthopedic surgery clinics were recruited. The primary outcome, proportion of patients with clinically meaningful decrease of at least 2 points on 0-10 visual analog scale (VAS) for pain, was compared between treatment groups at 2 months using comparison of proportions test and for all efficacy timepoints (2, 3, and 4 months) using generalized estimating equations (GEE). Secondary outcomes of global assessment, function, and quality of

SUBMITTER: Singh JA 

PROVIDER: S-EPMC3018709 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature