RSEQtools: a modular framework to analyze RNA-Seq data using compact, anonymized data summaries.

ABSTRACT:

Summary

The advent of next-generation sequencing for functional genomics has given rise to quantities of sequence information that are often so large that they are difficult to handle. Moreover, sequence reads from a specific individual can contain sufficient information to potentially identify and genetically characterize that person, raising privacy concerns. In order to address these issues, we have developed the Mapped Read Format (MRF), a compact data summary format for both short and long read alignments that enables the anonymization of confidential sequence information, while allowing one to still carry out many functional genomics studies. We have developed a suite of tools (RSEQtools) that use this format for the analysis of RNA-Seq experiments. These tools consist of a s

SUBMITTER: Habegger L 

PROVIDER: S-EPMC3018817 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature