Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.

ABSTRACT: Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Togethe

SUBMITTER: Liu Q 

PROVIDER: S-EPMC3019112 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature