Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis.

ABSTRACT:

Objective

To analyse the available evidence on cardiovascular safety of non-steroidal anti-inflammatory drugs.

Design

Network meta-analysis.

Data sources

Bibliographic databases, conference proceedings, study registers, the Food and Drug Administration website, reference lists of relevant articles, and reports citing relevant articles through the Science Citation Index (last update July 2009). Manufacturers of celecoxib and lumiracoxib provided additional data.

Study selection

All large scale randomised controlled trials comparing any non-steroidal anti-inflammatory drug with other non-steroidal anti-inflammatory drugs or placebo. Two investigators independently assessed eligibility.

Data extraction

The primary outcome was myocardial infarction. Secondar

SUBMITTER: Trelle S 

PROVIDER: S-EPMC3019238 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature