Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization.

ABSTRACT:

Background

Pulmonary edema and associated impaired oxygenation are a major reason for rejection of donor lung allografts offered for transplantation. Clearance of pulmonary edema can be upregulated by stimulation of β-adrenergic receptors (βARs). Single-nucleotide polymorphisms (SNPs) in βAR genes have functional effects in vitro and in vivo. We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation.

Methods

Nine hundred fifty-one organ donors were genotyped for 4 amino-acid-coding SNPs in the βAR genes. Lung allograft utilization was compared among donors stratified by genotypes.

Results

Utilization of donor lung allografts was 55% vs 35% (p = 0.02) among donors with GG vs AA/AG genotypes

SUBMITTER: Sapru A 

PROVIDER: S-EPMC3019270 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature