Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function.

ABSTRACT: An early lesion in many kidney diseases is damage to podocytes, which are critical components of the glomerular filtration barrier. A number of proteins are essential for podocyte filtration function, but the signaling events contributing to development of nephrotic syndrome are not well defined. Here we show that class II phosphoinositide 3-kinase C2α (PI3KC2α) is expressed in podocytes and plays a critical role in maintaining normal renal homeostasis. PI3KC2α-deficient mice developed chronic renal failure and exhibited a range of kidney lesions, including glomerular crescent formation and renal tubule defects in early disease, which progressed to diffuse mesangial sclerosis, with reduced podocytes, widespread effacement of foot processes, and modest proteinuria. These findings were assoc

SUBMITTER: Harris DP 

PROVIDER: S-EPMC3019860 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature