Phylogeography of the spring and fall waves of the H1N1/09 pandemic influenza virus in the United States.

ABSTRACT: Spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. However, the unprecedented intensity of sampling and whole-genome sequencing of the H1N1/09 pandemic virus now makes such an approach possible. To determine whether the spring and fall waves of the H1N1/09 influenza pandemic were associated with different epidemiological patterns, we undertook a large-scale phylogeographic analysis of viruses sampled from three localities in the United States. Analysis of genomic and epidemiological data reveals distinct spatial heterogeneities associated with the first pandemic wave, March to July 2009, in Houston, TX, Milwaukee, WI, and New York State. In Hou

SUBMITTER: Nelson MI 

PROVIDER: S-EPMC3020026 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature