Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer.

ABSTRACT: Over recent years, genome-wide association studies have contributed to our understanding of genetic susceptibility to sporadic cancer. In this study, we assessed the association between upper gastrointestinal cancer risk and four genome-wide association studies-identified single nucleotide polymorphisms (SNPs), implicated earlier in prostate and colorectal cancer susceptibility. Genotyping for each SNP was performed in two independent Caucasian population-based case-control studies. The first study comprised 290 gastric cancer cases and 374 controls. The second study included 185 noncardia gastric cancers, 123 cardia cancers, 158 oesophageal cancers and 209 controls. Odds ratios (ORs) were computed from logistic models and adjusted for potential confounding variables. An inverse associatio

SUBMITTER: Lochhead P 

PROVIDER: S-EPMC3020097 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature