Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.

ABSTRACT:

Aim

To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease (IBD).

Methods

Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls. Odds ratio (OR) and 95% CI were estimated by logistic regression models.

Results

The PXR A7635G variant, the PPARγ Pro12Ala and LXR T-rs2695121-C ho

SUBMITTER: Andersen V 

PROVIDER: S-EPMC3020373 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature