Distinguishing Menetrier's disease from its mimics.

ABSTRACT:

Objective

Ménétrier's disease (MD) is a rare hypertrophic gastropathy characterised by giant rugal folds, hypochlorhydria, protein loss and a classic constellation of symptoms (nausea, vomiting, abdominal pain and peripheral oedema). It is considered a clinical diagnosis that may at times be difficult to establish. Firm diagnostic criteria for MD are proposed by delineating the clinicopathological features that best differentiate MD from its mimics.

Method

48 patients referred to Vanderbilt University Medical Center for consideration of enrolment in a clinical trial of treatment of patients with MD with cetuximab were evaluated for a definitive diagnosis by assessing the clinical presentation, pertinent laboratory values and histopathological features.

Results

MD was

SUBMITTER: Rich A 

PROVIDER: S-EPMC3020399 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature