Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry.

ABSTRACT: We have established that human cytomegalovirus (HCMV) infection modulates the biology of target primary peripheral blood monocytes, allowing HCMV to use monocytes as "vehicles" for its systemic spread. HCMV infection of monocytes results in rapid induction of phosphatidylinositol-3-kinase [PI(3)K] and NF-κB activities. Integrins, which are upstream of the PI(3)K and NF-κB pathways, were shown to be involved in HCMV binding to and entry into fibroblasts, suggesting that receptor ligand-mediated signaling following viral binding to integrins on monocytes could trigger the functional changes seen in infected monocytes. We now show that integrin engagement and the activation of the integrin/Src signaling pathway are essential for the induction of HCMV-infected monocyte motility. To investigate

SUBMITTER: Nogalski MT 

PROVIDER: S-EPMC3020497 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature