Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques.

ABSTRACT: The first influenza pandemic of the new millennium was caused by a newly emerged swine-origin influenza virus (SOIV) (H1N1). This new virus is characterized by a previously unknown constellation of gene segments derived from North American and Eurasian swine lineages and the absence of common markers predictive of human adaptation. Overall, human infections appeared to be mild, but an alarming number of young individuals presented with symptoms atypical for seasonal influenza. The new SOIV also showed a sustained human-to-human transmissibility and higher reproduction ratio than common seasonal viruses, altogether indicating a higher pathogenic potential for this newly emerged virus. To study the virulence of the SOIV, we used a recently established cynomolgus macaque model and compared pa

SUBMITTER: Safronetz D 

PROVIDER: S-EPMC3020514 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature