Initial identification and characterization of an emerging zoonotic influenza virus prior to pandemic spread.

ABSTRACT: Two cases of febrile respiratory illness associated with untypeable influenza A virus were identified in Southern California in March 2009. One was initially detected as influenza virus using an experimental diagnostic device in a clinical trial, while the other was detected at a local reference lab using a diagnostic PCR assay. In both cases, analyses yielded negative results for strain-specific tests targeting circulating strains of influenza A virus (seasonal H1 and H3). These two samples became the first reported cases of the pandemic 2009/H1N1 influenza virus. The first reportable characterization was made from the second collected specimen on 15 April 2009 at the Centers for Disease Control and Prevention central lab using traditional culture and sequencing methods. The novel nature

SUBMITTER: Metzgar D 

PROVIDER: S-EPMC3020883 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature