Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins.

ABSTRACT:

Background

The discovery and characterisation of factors governing innate immune responses in insects has driven the elucidation of many immune system components in mammals and other organisms. Focusing on the immune system responses of the malaria mosquito, Anopheles gambiae, has uncovered an array of components and mechanisms involved in defence against pathogen infections. Two of these immune factors are LRIM1 and APL1C, which are leucine-rich repeat (LRR) containing proteins that activate complement-like defence responses against malaria parasites. In addition to their LRR domains, these leucine-rich repeat immune (LRIM) proteins share several structural features including signal peptides, patterns of cysteine residues, and coiled-coil domains.

Results

The identification

SUBMITTER: Waterhouse RM 

PROVIDER: S-EPMC3020904 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature