Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis.

ABSTRACT:

Background

Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC.

Objective

We conducted this proof-of-principle study to seek evidence of obesity-associated colorectal inflammation and to evaluate effects of diet-induced weight loss.

Design

We measured inflammatory cytokines, gene arrays, and macrophage infiltration in rectosigmoid mucosal biopsies of 10 obese premenopausal women [mean ± SD body mass index (in kg/m(2)): 35 ± 3.5] before and after weight loss induced by a very-low-calorie diet.

Results

Subjects lost a mean (±SD) of 10.1 ± 1% of their initial weight. Weight loss significantly reduced

SUBMITTER: Pendyala S 

PROVIDER: S-EPMC3021422 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature