Clinical outcomes of a 2-y soy isoflavone supplementation in menopausal women.

ABSTRACT:

Background

Soy isoflavones are naturally occurring phytochemicals with weak estrogenic cellular effects. Despite numerous clinical trials of short-term isoflavone supplementation, there is a paucity of data regarding longer-term outcomes and safety.

Objective

Our aim was to evaluate the clinical outcomes of soy hypocotyl isoflavone supplementation in healthy menopausal women as a secondary outcome of a trial on bone health.

Design

A multicenter, randomized, double-blind, placebo-controlled 24-mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg aglycone equivalent soy hypocotyl isoflavones plus calcium and vitamin D on the health of 403 postmenopausal women. At baseline and after 1 and 2 y, clinical blood chemistry values were measur

SUBMITTER: Steinberg FM 

PROVIDER: S-EPMC3021428 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature