Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.

ABSTRACT: The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.

SUBMITTER: Pradhan AD 

PROVIDER: S-EPMC3021499 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature