Associations of progesterone receptor polymorphisms with age at menarche and menstrual cycle length.

ABSTRACT:

Background

Age at menarche and menstrual cycle characteristics are indicators of endocrine function and may be risk factors for diseases such as reproductive cancers. The progesterone receptor gene (PGR) has been identified as a candidate gene for age at menarche and menstrual function.

Methods

Women office workers ages 19-41 self-reported age at menarche and participated in a prospective study of menstrual function and fertility. First-morning urine was used as the DNA source. 444 women were genotyped for a functional variant in PGR, rs1042838 (Val660Leu), and 264 women were also genotyped for 29 other SNPs across the extended gene region.

Results

Genetic variation across PGR was associated with age at menarche using a global score statistic (p = 0.03 among non-Hispa

SUBMITTER: Taylor KC 

PROVIDER: S-EPMC3021500 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature