Emergence of classical BSE strain properties during serial passages of H-BSE in wild-type mice.

ABSTRACT:

Background

Two distinct forms of atypical spongiform encephalopathies (H-BSE and L-BSE) have recently been identified in cattle. Transmission studies in several wild-type or transgenic mouse models showed that these forms were associated with two distinct major strains of infectious agents, which also differed from the unique strain that had been isolated from cases of classical BSE during the food-borne epizootic disease.

Methodology/principal findings

H-BSE was monitored during three serial passages in C57BL/6 mice. On second passage, most of the inoculated mice showed molecular features of the abnormal prion protein (PrP(d)) and brain lesions similar to those observed at first passage, but clearly distinct from those of classical BSE in this mouse model. These features we

SUBMITTER: Baron T 

PROVIDER: S-EPMC3021503 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature