The menin tumor suppressor protein is phosphorylated in response to DNA damage.

ABSTRACT:

Background

Multiple endocrine neoplasia type 1 (MEN1) is a heritable cancer syndrome characterized by tumors of the pituitary, pancreas and parathyroid. Menin, the product of the MEN1 gene, is a tumor suppressor protein that functions in part through the regulation of transcription mediated by interactions with chromatin modifying enzymes.

Principal findings

Here we show menin association with the 5' regions of DNA damage response genes increases after DNA damage and is correlated with RNA polymerase II association but not with changes in histone methylation. Furthermore, we were able to detect significant levels of menin at the 3' regions of CDKN1A and GADD45A under conditions of enhanced transcription following DNA damage. We also demonstrate that menin is specifically pho

SUBMITTER: Francis J 

PROVIDER: S-EPMC3021530 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature