Association of genetic polymorphisms of eNOS with glaucoma.

ABSTRACT:

Purpose

Several studies suggest that vascular dysregulation play a role in the etiology of glaucoma. In the present study, we aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG).

Methods

There were 102 POAG and 88 PCAG patients, diagnosed on the basis of clinical history, raised intraocular pressure (IOP), cup-to-disc ratio (CDR) and visual field defects, and 120 age- and sex-matched control subjects genotyped for 5 tagging single nucleotide polymorphisms (SNPs; rs743507, rs3793342, rs11771443, rs7830, and rs3918188) of the human eNOS gene.

Results

rs3793342, rs743507, rs11771443, rs7830, and rs3918188 were not found to be associated with PO

SUBMITTER: Liao Q 

PROVIDER: S-EPMC3021569 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature