Regulatory T cells can prevent memory CD8+ T-cell-mediated rejection following polymorphonuclear cell depletion.

ABSTRACT: Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which are amenable to suppression by Treg, remains unknown. Here, we show that accelerated graft rejection mediated by CD8(+) Tm was due to the enhanced recruitment of PMN to allografts in a mouse skin allograft model. Importantly, depletion of PMN slowed the kinetics of (but did not prevent) rejection mediated by Tm and created a window of opportunity that allowed subsequent suppression of rejection by Treg. Taken together, we conclude that CD8(+) Tm are not intrinsically resistant t

SUBMITTER: Jones ND 

PROVIDER: S-EPMC3021718 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature