Water prescription in autosomal dominant polycystic kidney disease: a pilot study.

ABSTRACT:

Background and objectives

In animal models of polycystic kidney disease, the ingestion of large amounts of water promotes diuresis by suppressing plasma levels of arginine vasopressin (AVP) and renal levels of cAMP, slowing cyst progression. Whether simple water ingestion is a potential therapeutic strategy for individuals with autosomal dominant polycystic kidney disease (ADPKD) is unknown. In this study, a simple method to quantify the amount of water to achieve a specific mean urine osmolality target in patients with ADPKD was developed and tested.

Design, setting, participants, & measurements

In eight ADPKD patients eating typical diets, osmolality and volume were measured in 24-hour urine collections. The amount of additional ingested water required daily to achieve a m

SUBMITTER: Wang CJ 

PROVIDER: S-EPMC3022242 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature