Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder.

ABSTRACT:

Background

Urothelial carcinoma (UC) can arise at any location along the urothelial tract, including the urethra, bladder, ureter, or renal pelvis. Although tumors arising in these various locations have similar morphology, it is unclear whether the gene expression profiles are similar between the upper-tract (ureter and renal pelvis) and lower-tract (bladder and urethra) carcinomas. Because differences may facilitate different screening and treatment modalities, we sought to examine the relationship between urothelial carcinoma of the renal pelvis (rUC) and urothelial carcinoma of the bladder (bUC).

Methods

Fresh tumor tissue was collected from patients with bUC (n = 10) and benign mucosa from the bladder of individuals undergoing resection for non-UC conditions (n = 7). Ge

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3022544 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature