Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide.

ABSTRACT:

Background

Mannan-binding lectin (MBL) is a pattern-recognition molecule present in serum, which is involved in the innate immune defense by activating complement and promoting opsonophagocytosis. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that are crucial for the initiation of adaptive immunity. Lipopolysaccharide (LPS) has been shown to be a strong activator of the inflammatory response and immune regulation. We first examined whether MBL modulated LPS-induced cellular responses, then investigated possible mechanisms of its inhibitory effect.

Results

MBL at higher concentrations (10-20 μg/ml) significantly attenuated LPS-induced maturation of monocyte-derived DCs (MDCs) and production of proinflammatory cytokines (e.g., IL-12 and TNF-α), and inh

SUBMITTER: Wang M 

PROVIDER: S-EPMC3022617 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature