The exopolyphosphatase TbrPPX1 of Trypanosoma brucei.

ABSTRACT:

Background

Exopolyphosphatases and pyrophosphatases play important but still incompletely understood roles in energy metabolism, and also in other aspects of cell biology such as osmoregulation or signal transduction. Earlier work has suggested that a human exopolyphosphatase, Prune, might exhibit cyclic nucleotide phosphodiesterase activity.

Results

The kinetoplastida, a large order of unicellular eukaryotes that contains many important pathogens such as Trypanosoma brucei (human sleeping sickness), Trypanosoma cruzi (Chagas disease) or Leishmania ssp (several clinically dinstinct leishmaniases) all contain several exo- and pyrophosphatases. The current study provides a systematic classification of these enzymes, which now allows to situate the information that is already a

SUBMITTER: Luginbuehl E 

PROVIDER: S-EPMC3022644 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature